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1jq3

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nat.Struct.Biol. 9 27-31 2002
    Site MCSG
    PDB Id 1jq3 Target Id
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    Related PDB Ids 1inl 
    Molecular Characteristics
    Source
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    Alias Ids
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    TPS4425,AAD35738, 2336
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 4
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.48 Rfactor 0.1960000
    Waters
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    Solvent Content 50.42

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    Ligand Information
    Ligands AAT (S-ADENOSYL-1,8-DIAMINO-3-THIOOCTANE) x 3
    Metals

    Jmol

     
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    Google Scholar output for 1jq3
    1. SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold
    JL Martin, FM McMillan - Current opinion in structural biology, 2002 - Elsevier
     
    2. Structure and mechanism of spermidine synthases
    H Wu, J Min, Y Ikeguchi, H Zeng, A Dong - Biochemistry, 2007 - ACS Publications
     
    3. Conformational selection in silico: loop latching motions and ligand binding in enzymes
    S Wong, MP Jacobson - Proteins: Structure, Function, and , 2008 - Wiley Online Library
     
    4. Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase
    PB Burger, LM Birkholtz, F Joubert, N Haider - Bioorganic & medicinal , 2007 - Elsevier
     
    5. Are structural biases at protein termini a signature of vectorial folding?
    A Laio, C Micheletti - PROTEINS: Structure, Function, and , 2006 - Wiley Online Library
     
    6. Mammalian Spermidine SynthaseIdentification of Cysteine Residues and Investigation of the Putrescine Binding Site
    H Goda, T Watanabe, N Takeda, M Kobayashi - Biological and , 2004 - J-STAGE
     
    7. A fold-recognition approach to loop modeling
    C Levefelt, D Lundh - Journal of molecular modeling, 2006 - Springer
     
    8. Low-molecular-weight spies of protein-protein interactions
    J Blobel, R Fayos, J Garca, O Marimon, Y Prez - Comptes Rendus , 2008 - Elsevier
     
    9. Comparative protein modeling of spermidine synthase from Plasmodium falciparum: A potential target for anti-malarial drug therapy
    DMR Reddy - Bioinformation, 2006 - ncbi.nlm.nih.gov
     
    10. The crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate-binding pocket
    X Zhou, TK Chua, KL Tkaczuk, JM Bujnicki - Journal of structural , 2010 - Elsevier
     
    11. A leishmaniasis study: Structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase
    A Grover, SP Katiyar, SK Singh, VK Dubey - Biochimica et Biophysica , 2012 - Elsevier
     
    12. PZ Kozbial, AR Mushegian - BMC structural biology, 2005 - BioMed Central Ltd
    79
     
    13. Conformational Sampling of Flexible Ligand-binding Protein Loops
    GR Lee, WH Shin, H Park, S Shin - Bull. Korean Chem. , 2012 - newjournal.kcsnet.or.kr
     

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    Protein Summary


    Ligand Summary

    Reviews

    References

     

    No references found.

    Tag page

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