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PDB Keyword
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3d8p

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of acetyltransferase of GNAT family (NP_373092.1) from STAPHYLOCOCCUS AUREUS MU50 at 2.20 A resolution. To be published
    Site JCSG
    PDB Id 3d8p Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1749,NP_373092.1, 89059
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 3.08 Rfactor 0.172
    Waters
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    Solvent Content 60.06

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3d8p

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    Protein Summary

    Acetyltransferase of GNAT family, where Tyr129 (corresponds to Tyr141 in PDB:1tiq) is predicted as the catalytic residue. NP_373092.1 is from Staphylococcus aureus mu50.  Based on sequence alignment from NCBI blast and the predicted homologues Fold & Function Assignment System (FFAS and SSM), this target is structurally similar to 1TIQ, 1YR0, 2OB0, 2PSW and 2Q7B, which are acetyltransferase protein most likely.  Both SEC data and interaction interface calculation suggest the biomolecule of NP_373092.1 is a monomer.

        

    379875_1.png

        

    Figure 1. Biomolecule of protein NP_373092.1 should be a monomer. 

        

    379875_2.png

    Figure 2. Protein NP_373092.1(Green) is a structural homolog to those acetyltransferase, such as 1TIQ, 1YR0, 2OB0, 2PSW and 2Q7B.

    Ligand Summary

    Ca2+, Acetate ions

    References

    Forouhar, F.,  Lee, I.S.,  Vujcic, J.,  Vujcic, S.,  Shen, J.,  Vorobiev, S.M.,  Xiao, R.,  Acton, T.B.,  Montelione, G.T.,  Porter, C.W.,  Tong, L.  (2005) Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase.  J.Biol.Chem.  280: 40328-40336 

    Reviews

    References

     

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    139.5 kB18:49, 4 Sep 2008kevinjinActions
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    189.8 kB18:49, 4 Sep 2008kevinjinActions
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