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3d1c

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Flavin-containing Putative Monooxygenase (NP_373108.1) from STAPHYLOCOCCUS AUREUS MU50 at 2.40 A resolution. To be published
    Site JCSG
    PDB Id 3d1c Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1767,NP_373108.1, BIG_357, 283046
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 3.12 Rfactor 0.181
    Waters
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    Solvent Content 60.57

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3d1c
    1. A Flavoprotein Monooxygenase that Catalyses a BaeyerVilliger Reaction and Thioether Oxidation Using NADH as the Nicotinamide Cofactor
    CN Jensen, J Cartwright, J Ward, S Hart - , 2012 - Wiley Online Library
     
    2. Distributed structure determination at the JCSG
    H van den Bedem, G Wolf, Q Xu - Section D: Biological , 2011 - scripts.iucr.org
     

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    Protein Summary

    NP_373108.1 is a likely  flavin-containing monooxygenase  (FMO), it is structurally similar to FMO from S. pombe (RMSD 2.36 for 264 aligned Ca, PDB code 2gvc/1vqw/2gv8). The solved structure contains a FAD. It also contains an unidentified ligand at the same place of methimazole in SmFMO. The active site residues,  though somewhat similar to SmFMO, are not completely conserved, suggesting possible differences in substrate specificity. O2*,O3*,O4* positions of FAD in this enzyme also differs from SmFMO.

    NP_373108.1 functions as a monomer. It may also bind NADPH or NADH (NP_373108.1 contains a Pyridine nucleotide-disulphide oxidoreductase (PF07992: Pyr_redox_2) domain from Pfam, which according to Pfam is a small NADH binding domain within a larger FAD binding domain. 





    Ligand Summary



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