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PDB Keyword
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3ct8

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of a Putative Glyoxalase (NP_243026.1) from Bacillus halodurans at 2.10 A resolution. To be published
    Site JCSG
    PDB Id 3ct8 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1515,NP_243026.1, 86355
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.21 Rfactor 0.216
    Waters
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    Solvent Content 44.37

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3ct8

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    Protein Summary

    The protein is currently classified as an unknown conserved protein. However, based on sequence analysis, it belongs to PFAM PF00903 (http://pfam.sanger.ac.uk/family?acc=PF00903) which is the family of  Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. The protein seems to have two short domains (see Fig 1). Each domain is composed of a three-stranded sheet and a helix. A Zn ion is bound in the C-terminal domain. The biological unit is a dimer (see Fig 2).

    Fig 1. Monomer structure with Zn and an unknown ligand shown.

    Fig 2. Dimer of protein is the biologically relevant unit.

    Several homlogs of this protein exist. A few (1xqa 2rk0 2p7k 2p7l 2p7q) are shown below in Fig 3.


    Fig 3. Structural homologs superimposed on the protein (in green). The metal ions are shown as spheres. 1xqa has MG ion and 2p7q has MN ion bound at the Zn site.


    Ligand Summary

    ZN is bound to the protein. In homologous structures, the same site is occupied by other metals.
    There is a peptide like density coordinating ZN. This density may represent a biological substrate. An unknown ligand (UNL) has been modeled in this density.

    References

    Reviews

    References

     

    No references found.

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