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The Open Protein Structure Annotation Network
PDB Keyword
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3cny

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Putative Inositol Catabolism Protein IolE (NP_786806.1) from Lactobacillus plantarum at 1.85 A resolution. To be published
    Site JCSG
    PDB Id 3cny Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1768,NP_786806.1, _0023.000408_
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.38 Rfactor 0.165
    Waters
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    Solvent Content 48.30

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3cny

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    Protein Summary

    The iolE (lp_3607) gene from Lactobacillus plantarum encodes the NP_786806.1 amino acid sequence that folds into a putative inosose dehydratase IolE , an enzyme involved in inositol metabolism. IolE catalyzes the following reaction:

    scyllo-inosose ---> D-2,3-Diketo-4-dexyo-epi-inositol

    Genome context analysis shows the iolE gene as part of the iol operon of L. plantarum. NP_786806.1 shares sequence similarity with the AP_endonuc_2  family (PF01261) from Pfam, annotated as xylose isomerase-like TIM barrels.

    3cny structure belongs to the SCOP TIM barrel fold, xylose isomerase-like superfamily, IolI-like family. A DALI search for structural similarity returns the AsbF protein

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    as top hit (Z=25), followed by xylose isomerase
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    and TM0416 protein
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    . 3cny bears structural similarity to many TIM barrel proteins such as the YGBM protein 1k77, the tagatose epimerase 2qul and the IolI protein 1i60 (Z=24), despite lack of sequence homology.


    The active site can be identified by comparison with the active site in the homologs (DxxH--//--HxxD). 3cny putative active site configuration is similar to
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    and
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    . However, not all residues are identical. For example, H159 of 3cny corresponds to Asp in 2qul and 1i60. The putative active site is buried between the N and C termini interfaces. There is a solvent channel for access.



     

    Ligand Summary

     

    References

    Reviews

    References

     

    No references found.

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