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The Open Protein Structure Annotation Network
PDB Keyword
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3c18

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of nucleotidyltransferase-like protein (ZP_00538802.1) from Exiguobacterium sibiricum 255-15 at 1.90 A resolution. To be published
    Site JCSG
    PDB Id 3c18 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1690,YP_001813159.1, 382972
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 3
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.84 Rfactor 0.183
    Waters
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    Solvent Content 56.69

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3c18
    1. Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB
    M Morar, K Bhullar, DW Hughes, M Junop, GD Wright - Structure, 2009 - Elsevier
     
    2. Structure of the adenylylation domain of E. coli glutamine synthetase adenylyl transferase: evidence for gene duplication and evolution of a new active site
    Y Xu, PD Carr, SG Vasudevan, DL Ollis - Journal of molecular biology, 2010 - Elsevier
     
    3. 9-Substituted 6, 6-Dimethyl-11-oxo-6, 11-dihydro-5H-benzo [b] carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors
    K Kinoshita, T Kobayashi, K Asoh - Journal of medicinal , 2011 - ACS Publications
     
    4. Structure and Function of the Cardiac Stress Response Protein MS1
    CLF Fogl - 2011 - lra.le.ac.uk
     

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    Protein Summary

    377609 encondes a hypothetical protein of unknown function with 289 residues. The structure is comprised of three domains. The smaller N-terminal domain (residues 1-113) contains a four stranded beta sheet packed between four helices (shown in orange in figure 1 below). The central domain (residues 114-216) resembles a four-helix bundle, and the C-terminal domain (residues 217-289) with additional helices and a small beta sheet attached, resembles DNA-binding domains (with similarity to PDB:2hzt). The central and C-terminal domains are shown in blue in figure 1 below.


    Figure 1. Monomeric form of 377609, with N-term shown in orange, and c-term in blue.

    Based on a structural comparison with 1KNY, it is possible to get some information about the basic fold for the two domains. Based on SCOP, the N-terminal domain appears to form a nucleotidyltransferase fold, while the C-terminal domain takes a four-helical up-and-down bundle fold. The N-teminal and central domain of 377609 has to be twisted to obtain complete superposition with PDB:1KNY. The putative DNA binding domain of 377609 is absent in protein structure 1KNY.

    The oligomeric form of 377609 is a dimer (figure 2), with 1.5 dimers present the crystallographic
    ASU. The dimer creates a very large cavity, ~10227A3.


    Figure 2. The dimer, with the A chain in blue and the B chain in orange.

    Ligand Summary



    References

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