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3bo9

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of putative nitroalkan dioxygenase (TM0800) from Thermotoga maritima at 2.71 A resolution. To be published
    Site JCSG
    PDB Id 3bo9 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1234,TM0800, 90090, 85010
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 4.63 Rfactor 0.189
    Waters
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    Solvent Content 73.44

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3bo9

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    Protein Summary

    putative nitroalkan dioxygenaseProduct of conserved gene ( FabK of E.coli). Very important participant of Fatty Acid Biosynthesis(FASII). Genome and functional context is perfect:clustering on a chromosome with FabD - Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)(TM0798), FabZ - (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase (EC 4.2.1.-) (TM0801), FabF - 3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.41) (TM0802)

    TM0800 is 35% seq identical to 2gjl/2gjn. It is structurally similar to 2gjl/2gjn. The active site residues are conserved, including H146 and the site binding FMN. TM0800 has residual density resemble FMN, but the riboflavin part is highly disordered (thus not modeled).  Thus TM0800 is also likely a deoxygenase.

    Additionally study suggested:

    co-xtallization with FMN
    derive substrate identity from constructed pathway


    Ligand Summary



    References

    Reviews

    References

     

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