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3bby

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of glutathione S-transferase (NP_416804.1) from Escherichia coli K12 at 1.85 A resolution. To be published
    Site JCSG
    PDB Id 3bby Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1737,NP_416804.1, 86872
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.64 Rfactor 0.158
    Waters
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    Solvent Content 53.46

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3bby

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    Protein Summary

    The yfcF from Escherichia coli k12encodes glutathione S-transferase (subfamily 4).

    This structure is structural and sequentially homologous to Glutathione S-transferase (GST, eg 6gss) 

    The A71 (glu) is important by structural alignment, also A71 is a clearly defined Ramachandran outlier. It is interesting to note that 40-57 is disordered, this seems to correlate with empty active site, it is likely that this segment is important for substrate binding.

    PFAM entry http://pfam.sanger.ac.uk/family?acc=PF02798

    Putative catalytic tyrosine is Tyr18.  The additional analysis needs to be done to confirm Arg58 role in GSH binding.


    Ligand Summary



    References

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