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The Open Protein Structure Annotation Network
PDB Keyword
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3b5q

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of a putative sulfatase (NP_810509.1) from Bacteroides thetaiotaomicron VPI-5482 at 2.40 A resolution. To be published
    Site JCSG
    PDB Id 3b5q Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1685,NP_810509.1, 335720
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.90 Rfactor 0.149
    Waters
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    Solvent Content 57.61

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3b5q

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    Protein Summary

    The BT_1596 gene from Bacteroides thetaiotaomicron vpi-5482 encodes a putative sulfatase (PF00884, COG3119) that adopts an alkaline phosphatase-like fold and shows significant structural similarity with human aryl sulfatase A (PDB id: 1AUK), an enzyme implicated in a lysosomal storage disorder [Ref], and other human lysosomal sulfatases (PDB id: 1FSU, [Ref]).

     

    To do: look for any microarray, proteomics etc. data in homologs to further define function; look at conservation of unusually modified aminoacid (formylglycine) - is there any extra density present that might suggest formylation?

    Ligand Summary


    References

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    References

     

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