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2pyt

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Ethanolamine utilization protein eutQ (16421009) from Salmonella typhimurium LT2 at 1.90 A resolution. To be published
    Site JCSG
    PDB Id 2pyt Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1638,16421009, PF06249, 2.60.120.10
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.02 Rfactor 0.173
    Waters
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    Solvent Content 38.97

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2pyt
    1. Crystal structure of the EutL shell protein of the ethanolamine ammonia lyase microcompartment
    M Sagermann, A Ohtaki - Proceedings of the , 2009 - National Acad Sciences
     

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    Protein Summary

    The eutQ gene from Salmonella typhimurium lt2 (NP_461403) encodes a 229 residue ethanolamine utilization protein (PF06249, COG1917) whose C-terminal fragment 98-229 adopts a double-stranded beta-helix fold, inside the RmlC-like cupins superfamily, EutQ-like family. The eutQ gene forms part of the ethanolamine utilization operon, members of which have been implicated in the formation of a protein-based organelle (microcompartment) in E. coli [Ref] leading to sequestration of ethanolamine metabolism [Ref]. In Salmonella, 5 out of the 17 eut operon genes are apparent homologues of proteins that serve (in other organisms) as shell proteins of the carboxysome [Ref] suggesting CO2 fixation may be a feature of ethanolamine catabolism in Salmonella. STRING finds a strong hit (0.984) based on neighborhood, co-ocurrence and coexpression with eutT, a putative cobalamin adenosyltransferase (YP_149724).

     

    Strong structural similarity (FFAS scr=-30; Dali Z-scr=13; FATCAT P-val=2e-8) is detected with 1vj2, a manganese containing cupin [Ref], 3bcw and 1o5u([Ref]).

     

    To do: does eutQ have a cobalamin site? any other way to identify its function? look at similarity between eut operon and other bacterial microcompartment-forming operons - is there a big picture? (e.g. compare/contrast carboxysome with eut microcompartment)

    Ligand Summary


    References

    Reviews

    References

     

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