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The Open Protein Structure Annotation Network
PDB Keyword
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2pn2

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of uncharacterized protein (YP_263861.1) from Psychrobacter arcticus 273-4 at 2.15 A resolution. To be published
    Site JCSG
    PDB Id 2pn2 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1572,YP_263861.1, 103796
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.01 Rfactor 0.195
    Waters
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    Solvent Content 38.69

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2pn2
    1. Inhibition Mechanism of the Acetylcholine Receptor by _-Neurotoxins as Revealed by Normal-Mode Dynamics
    AO Samson, M Levitt - Biochemistry, 2008 - ACS Publications
     
    2. IN-SILICO PREDICTION OF STRUCTURAL AND FUNCTIONAL ASPECTS OF A HYPOTHETICAL PROTEIN OF CAPNOCYTOPHAGA CANIMORSUS CC5
    HH Pilley - Journal of Advanced Bioinformatics Applications and , 2011 - bipublication.com
     

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    Protein Summary

    Gene Psyc_0566 from Psychrobacter arcticus translates into the YP_263861 amino acid sequence that belongs to the large family of OsmC-like proteins (PF02566, COG1765, and COG1764). Proteins from this family are present mostly in bacteria, but also in protists, slime molds and fungi and are involved in oxidative / osmotic stress response and hydroperoxide detoxification. Interestingly, eukaryotic proteins from this family do not form a common sub-tree and appear to represent independent gene transfer events.


    Other proteins from this family solved by JCSG are 
    Thermotoga maritima protein TM0919 (1vla) and Thermoplasma acidiophilumprotein NP_393673.1 (2onf). Structurally, 2pn2 and its homologs (PDB structures 2onf, 1ml8, 2d7v, 1n2f, 1qwi, and 2opl) belong to the OsmC-like fold from alpha+beta class, Ohr/OsmC resistance family. Cysteines Cys53 and Cys115 from Psychrobacter arcticus  protein align with functionally important cysteines from other members of this family, suggesting a possible location of an active site.
     

     
     
     

    Ligand Summary



    References

    Reviews

    References

     

    No references found.

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