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The Open Protein Structure Annotation Network
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2icg

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of hypothetical protein (NP_472245.1) from Listeria Innocua at 1.65 A resolution. To be published
    Site JCSG
    PDB Id 2icg Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1532,NP_472245.1, BIG_234, BIG_12, 86217
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.57 Rfactor 0.198
    Waters
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    Solvent Content 52.13

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2icg
    1. A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems
    D Zhang, LM Iyer, L Aravind - Nucleic acids research, 2011 - Oxford Univ Press
     

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    Protein Summary

    The NP_472245 from L. innocua is a "founding member" of a large family (~250 homologs) of uncharacterized (hypothetical) proteins found mostly in gram positive bacteria, but also in fungi, termed SMI/KNR4 group (PF09346).  A domain homologous to this family is a second domain in a three domain COG family COG4282 (Proteins involved in beta-1,3-glucan synthesis).

     

    SCOP classifies 2icg inside the alpha+beta class, SMI/KNR4-like (super)family. JCSG solved a third protein from this family (2prv), while the NY center solved the second (2pag). Analysis of the crystallographic packing of 2icg using the PQS server {Henrick, 1998 #73} indicates that a hexamer, as a dimer of trimers in which each subunit makes significant contacts with four others, is the biologically relevant form. Alternatively, a different crystalographically generated dimer, mainly formed through hydrogen bonds between backbone atoms, could be biologically relevant. Neither structural homolog retains one of these quaternary structures.

    Ligand Summary



    References

    Reviews

    References

     

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