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2gm6

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of cysteine dioxygenase type I (YP_299237.1) from Ralstonia eutropha JMP134 at 1.84 A resolution. To be published
    Site JCSG
    PDB Id 2gm6 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1461,YP_299237.1, 2.60.120.10, PF05995, 90681
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 3.55 Rfactor 0.18
    Waters
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    Solvent Content 65.12

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2gm6
    1. An insight into the mechanism of human cysteine dioxygenase
    S Ye, X Wu, L Wei, D Tang, P Sun, M Bartlam - Journal of Biological , 2007 - ASBMB
     
    2. Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria
    JE Dominy Jr, CR Simmons, PA Karplus - Journal of , 2006 - Am Soc Microbiol
     
    3. Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity
    JE Dominy Jr, J Hwang, S Guo, LL Hirschberger - Journal of Biological , 2008 - ASBMB
     
    4. Cysteine dioxygenase: structure and mechanism
    CA Joseph, MJ Maroney - Chem. Commun., 2007 - xlink.rsc.org
     
    5. Thiol dioxygenases: unique families of cupin proteins
    MH Stipanuk, CR Simmons, P Andrew Karplus - Amino Acids, 2011 - Springer
     
    6. Structure and Function of Atypically Coordinated Enzymatic Mononuclear Non-heme-Fe (II) Centers
    D Buongiorno, G Straganz - Coordination Chemistry Reviews, 2012 - Elsevier
     
    7. Cysteine Dioxygenase: The Importance of Key Residues and Insight into the Mechanism of the Metal Center
    JH Leung - Masters Theses, 2008 - scholarworks.umass.edu
     

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    Protein Summary

    The Reut_B5045 (YP_299237.1) gene from Ralstonia eutropha encodes the enzyme cysteine dioxygenase type I PF05995 EC:1.13.11.20.  The enzyme contains cupin-like domain RmlC SCOP51182.  The enzyme catalyzes the following reaction: L-cysteine + O(2) <=> 3-sulfinoalanine.  This reaction is a branch-point in cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate.  3-sulfinoalanine-dependent pathway of taurine metabolism follows the synthesis of hypotaurine (2-aminoethane sulfinate), which is subsequently oxidized to taurine.

    Ligand Summary



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