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The Open Protein Structure Annotation Network
PDB Keyword
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2gd9

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of (2636623) from BACILLUS SUBTILIS at 2.30 A resolution. To be published
    Site JCSG
    PDB Id 2gd9 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1416,2636623, _0023.002889_, _0036.000262_, _0052.000516_, _0110.002040_, 85246
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 3.57 Rfactor 0.207
    Waters
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    Solvent Content 65.30

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2gd9

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    Protein Summary

    The gene BSU40760 (aka yyaP) from Bacillus subtilis encodes the NP_391956 protein, a putative dihydrofolate reductase PF01872, EC:1.5.1.3, COG0262.

    Pre-SCOP classifies 2gd9 in the alpha/beta class, dihydrofolatereductase-like (super)family. A DALI search hits with reductase like 3jtw (Z=18), and 3ky8 (Z=17). The crystal structure of the homologous enzyme from Thermotoga maritima is available 1D1G (Z=15). 

    Dihydrofolate reductase (DHFR) reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate because 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-methylenetetrahydrofolate.  The latter is then utilized by thymidylate synthase. Inhibition of DHFR interrupts thymidilate synthesis and DNA replication. Inhibitors of DHFR (such as methotrexate) are used in cancer chemotherapy. 5,6,7,8-tetrahydrofolate also is involved in glycine, serine, and threonine metabolism and aminoacyl-tRNA biosynthesis.

    Ligand Summary



    References

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