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The Open Protein Structure Annotation Network
PDB Keyword
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2fyx

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of a putative Transposase(6457846) from DEINOCOCCUS RADIODURANS at 1.90 A resolution. To be published
    Site JCSG
    PDB Id 2fyx Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1375,6457846, PF01797, 289629
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 3.27 Rfactor 0.16
    Waters
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    Solvent Content 62.08

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2fyx
    1. DNA recognition and the precleavage state during single-stranded DNA transposition in D. radiodurans
    AB Hickman, JA James, O Barabas, C Pasternak - The EMBO , 2010 - nature.com
     

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    Protein Summary

    The gene DR_0177 from Deinococcus radiodurans encodes the NP_293901 protein, a member of the IS200-like transposase group PF01797. Its genomic neighborhood shows the presence of an RNA polymerase sigma E factor (DR_0180) and a nucleoside triphosphatase (DR_0179).

    The 2fyx structure belongs to the class of alpha and beta (a+b) proteins and reveals ferredoxin-like fold type SCOP54861 inside the transposase IS200-like (super)family. The top hit in DALI is the transposase with PDB code 2ec2 (Z=17). Several structures of 2fyx homologues (33% seq. id.) have been solved: 2VHG, Helicobacter pylori (Z=15);  2A6MHelicobacter pylori (Z=16).

    Transposases are required for efficient transposition of the mobile DNA element.  

    Ligand Summary



    References

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