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The Open Protein Structure Annotation Network
PDB Keyword
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2ffj

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of (2649480) from ARCHAEOGLOBUS FULGIDUS at 2.45 A resolution. To be published
    Site JCSG
    PDB Id 2ffj Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1445,NP_069933.1
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.48 Rfactor 0.189
    Waters
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    Solvent Content 50.46

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2ffj

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    Protein Summary

    The AF1104 (NP_069933.1) gene from Archaeoglobus fulgidus encodes a protein of unknown function DUF89 PF01937.  The protein belongs to the class of multi-domain proteins (alpha and beta) and reveals AF1104-like fold type SCOP111320.  The structure of the protein contains two well-defined domain.  The C-terminal domain is an all-alpha 3-helical bundle, which is similar to  the immunoglobulin/albumin-binding domain-like fold SCOP46996.  The N-terminal domain in general looks similar in structure to the subunit of bacterial pilin family of proteins, although orientation of beta-sheets does not match 3JYZ.  Pilin is a component of pili.  Pili connect a bacterium to another of its species, or to another bacterium of a different species, and build a bridge between the interior of the cells. This enables the transfer of plasmids between the bacteria.

     

    Human homolog (Q9NVE7) is annotated as pantothenate kinase 4 (EC 2.7.1.33) as are other eukaryotic homologs, e.g. Q8L5Y9 in Arabidopsis thaliana and in Drosophila melanogaster. It has a lenght of more than 700 residues where from 35 to 370 resides the ROK kinase domain followed by the DUF89 (residues 450-760).

     

    DUF89 is fused with Fumble domain (PF03630) in 38 homologs (Pfam entries), putative phosphatase domain (PF06888) in 5 entries and other phosphatases (PF00316, PF00149) in 4 entries.

    Ligand Summary



    References

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