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The Open Protein Structure Annotation Network
PDB Keyword
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2etv

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of IRON(III) ABC transporter, periplasmic iron-binding protein, putative (tm0189) from THERMOTOGA MARITIMA at 1.70 A resolution. To be published
    Site JCSG
    PDB Id 2etv Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1390,TM0189
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.60 Rfactor 0.163
    Waters
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    Solvent Content 51.80

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2etv
    1. Characterization of a Bacillus subtilis transporter for petrobactin, an anthrax stealth siderophore
    AM Zawadzka, Y Kim, N Maltseva - Proceedings of the , 2009 - National Acad Sciences
     
    2. Trapping open and closed forms of FitEA group III periplasmic binding protein
    R Shi, A Proteau, J Wagner, Q Cui - Proteins: Structure, , 2009 - Wiley Online Library
     
    3. New surface contacts formed upon reductive lysine methylation: Improving the probability of protein crystallization
    P Sledz, H Zheng, K Murzyn, M Chruszcz - Protein , 2010 - Wiley Online Library
     
    4. Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634
    CJ McCleverty, L Columbus, A Kreusch - Protein , 2008 - Wiley Online Library
     

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    Protein Summary

    Gene TM0189 from Thermotoga maritima encodes the NP_228004 amino acid sequence which is similar to periplasmic binding proteins ( PF01497 ) from COG0614 (ABC-type Fe3+-hydroxamate transport system, periplasmic component) and also to the periplasmic component of ABC-type transport systems (COG4594, COG4592, COG4558, and COG4607). By genomic context and pattern of phylogenetic cooccurrence (STRING score 0.989), the functions of TM0189 may be interdependent with functions of TM0190 (putative Fe 3+ ABC transporter, permease protein) and TM0191 (putative Fe3+ ABC transporter, ATP-binding protein).

    SCOP classifies 2etv inside the alpha/beta class, chelatase-like fold, helical backbone metal receptor superfamily, TM0189-like family. Structures with significant similarity, apart from

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    (Z=17) and
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    (Z=18) [Ref] are (determined with DALI,  FATCAT and FFAS03):
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    (chain A, Z=15) and
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    (chain N, Z=17). Similar structures without significant sequence similarity are:
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    (chain A, Z=8) and
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     (chain A, Z=8). Other DALI top hits are with putative ABC transporters
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    (Z=19),
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    (Z=18),
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    (Z=18),
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    (Z=18).

    Ligand Summary



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