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The Open Protein Structure Annotation Network
PDB Keyword
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2b4a

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of BH3024 protein (10175646) from BACILLUS HALODURANS at 2.42 A resolution. To be published
    Site JCSG
    PDB Id 2b4a Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1407,10175646, 342259
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.54 Rfactor 0.182
    Waters
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    Solvent Content 51.29

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2b4a
    1. Receiver domain structure and function in response regulator proteins
    RB Bourret - Current opinion in microbiology, 2010 - Elsevier
     
    2. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches
    R Schwarzenbacher, A Godzik - Section D: Biological , 2007 - scripts.iucr.org
     
    3. Dimensionality reduction in computational demarcation of protein tertiary structures
    RR Joshi, PR Panigrahi, RN Patil - Journal of Molecular Modeling, 2011 - Springer
     

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    Protein Summary

    The gene BH3024 from Bacillus halodurans encodes a response regulator receiver domain (REC), a member of CheY clan ( PF00072).  

    2b4a structure belongs to the class of alpha and beta (a+b) proteins and adopts a flavodoxin-like fold type,  CheY-like (super)family SCOP52171. DALI top hits (Z=16) are with the response regulator

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    , the sensor protein
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    , the sporulation initiator phosphotransferase-F
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    , and the REC domain containing Che-Y like protein
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    .

    The REC domain receives the signal from the sensor partner in a two-component systems.  The domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs.  Within the genomic context, it is usually found N-terminal to a DNA binding effector domain.  Its biological unit is a homodimer.  CheY-like phosphoacceptor REC domain is a common module in a variety of response regulators of the bacterial signal transduction systems.  To date, 4,610 response regulators, encoded in complete genomes of 200 bacterial and archaeal species, have been identified [Ref].

    Ligand Summary



    References

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