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2b33

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Protein synthesis inhibitor, putative (tm0215) from THERMOTOGA MARITIMA at 2.30 A resolution. To be published
    Site JCSG
    PDB Id 2b33 Target Id 282095
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1192,TM0215, 289480 Molecular Weight 14267.64 Da.
    Residues 128 Isoelectric Point 5.12
    Sequence mkrfvetdkapkaigpysqavvvgnmmfvsgqipidpetgelvqgtieektervlenlkaileaggfsl kdvvkvtvfttsmdyfqrvnevysryfgdhrparsfvavaqlprnveieieaiavkege
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 2.30 Rfree 0.261
    Matthews' coefficent 1.98 Rfactor 0.199
    Waters 80 Solvent Content 37.52

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    Ligand Information
    Ligands
    Metals

    Jmol

     
    Google Scholar output for 2b33
    1. The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family
    J Burman, C Stevenson, RG Sawers - BMC structural , 2007 - biomedcentral.com
     

    Protein Summary

    The TM0125 gene from Thermotoga maritima codes for the NP_228030 protein, from the endoribonuclease L-PSP group PF01042, EC:3.1.26.12). 

    SCOP classifies 2b33 in the alpha+beta class, YjgF-like superfamily, YjgF/L-PSP family. DALI top hits are with the PH0854 protein 2dyy (Z=25), the protein ST0811 1x25 (Z=24), the YABJ protein 1qd9 (Z=24) and the translation initiation inhibitor YJGF 1xrg (Z=24).

    The enzyme acts on only the single-stranded mRNA and inhibits protein synthesis by cleavage of mRNA.  The modification of mRNA template induces disaggregation of the reticulocyte polysomes into 80S ribosomes, even in the presence of cycloheximide [Ref].  This endoribonuclease may also be involved in the regulation of purine biosynthesis [Ref].

    Ligand Summary



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