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The Open Protein Structure Annotation Network
PDB Keyword
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2acf

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. Structure 13 1665-1675 2005
    Site JCSG
    PDB Id 2acf Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1517,29837497
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 4
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.60 Rfactor 0.16414
    Waters
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    Solvent Content 51.00

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2acf
    1. Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1 _-phosphate dephosphorylation by a conserved domain of nsP3
    KS Saikatendu, JS Joseph, V Subramanian, T Clayton - Structure, 2005 - Elsevier
     
    2. The SARS-unique domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes
    J Tan, C Vonrhein, OS Smart, G Bricogne, M Bollati - PLoS , 2009 - dx.plos.org
     
    3. Crystal structures of the X_domains of a Group_1 and a Group_3 coronavirus reveal that ADP_ribose_binding may not be a conserved property
    Y Piotrowski, G Hansen - Protein , 2009 - Wiley Online Library
     
    4. Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold
    A Chatterjee, MA Johnson, P Serrano, B Pedrini - Journal of , 2009 - Am Soc Microbiol
     
    5. The coronavirus replicase gene: special enzymes for special viruses
    J Ziebuhr, EJ Snijder - Coronavirusesmolecular and cellular , 2007 - books.google.com
     
    6. Viral enzymes
    JR Mesters, J Tan, R Hilgenfeld - Current opinion in structural biology, 2006 - Elsevier
     

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    Protein Summary

    The gene 29837497 from Sars coronavirus encodes a conserved domain of nonstructural protein 3 (nsP3), a member of a macro family PF01661 SCOP52948.  The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ADP-ribose as a ligand. Previously identified as displaying an Appr-1"-p (ADP-ribose-1"-monophosphate) processing activity, the macro domain may play roles in distinct ADP-ribose pathways, such as the ADP-ribosylation of proteins, an important post-translational modification which occurs in DNA repair, transcription, chromatin biology, and long-term memory formation, among other processes.  The SARS nsP3 domain readily removes the 1'' phosphate group from Appr-1''-p in in vitro assays, confirming its phosphatase activity [Ref]

     

    According to DALI, structurally similar proteins (Zscr=22) to 2acf/2fav are other viral RNA binding proteins like 3jzt, 3ew5, or 3eti.

    Ligand Summary


    References

    Reviews

    References

     

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