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1zkg

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function. Proteins 68 418-424 2007
    Site JCSG
    PDB Id 1zkg Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1254,TM1030, 84786
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.60 Rfactor 0.201
    Waters
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    Solvent Content 52.25

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 1zkg
    1. Regulation of the Dha Operon of Lactococcus lactis
    S Christen, A Srinivas, P Bhler, A Zeller - Journal of Biological , 2006 - ASBMB
     
    2. A comprehensive analysis of structural and sequence conservation in the TetR family transcriptional regulators
    Z Yu, SE Reichheld, A Savchenko, J Parkinson - Journal of molecular , 2010 - Elsevier
     
    3. Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment
    KD Koclega, M Chruszcz, MD Zimmerman - Journal of structural , 2007 - Elsevier
     
    4. Crystal structure of TM1030 from Thermotoga maritima at 2.3 resolution reveals molecular details of its transcription repressor function
    L Premkumar, CL Rife, S Sri Krishna - Proteins: Structure, , 2007 - Wiley Online Library
     
    5. New insights into the structure, function and evolution of TETR family transcriptional regulators
    Z Yu - 2010 - 142.150.190.46
     

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    Protein Summary

    TM1030 is a TetR like transcription repressor. The  structure presented here describes the ligand-bound form of TM1030[Ref]. MCSG, independently determined the  structure of apo-TM1030[Ref]. A structure superposition of apo and ligand bound forms, reveals a dramatic conformational change upon ligand binding.

     

    Ligand Summary

    There are two UNLs present within the ligand binding pocket of each TM1030 monomer. Based on the shape of the electron density, it is likely a heptaethelene glycol.

    References

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