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The Open Protein Structure Annotation Network
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1zej

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of 3-hydroxyacyl-CoA dehydrogenase (HBD-9) (np_070841.1) from Archaeoglobus fulgidus at 2.00 A resolution. To be published
    Site JCSG
    PDB Id 1zej Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1359,NP_070841.1
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.88 Rfactor 0.179
    Waters
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    Solvent Content 56.93

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 1zej
    1. The Buccaneer software for automated model building. 1. Tracing protein chains
    K Cowtan - Acta Crystallographica Section D: Biological , 2006 - scripts.iucr.org
     
    2. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard
    TC Terwilliger, PD Adams, RJ Read - Section D: Biological , 2009 - scripts.iucr.org
     
    3. Dimeric Crystal Structure of Rabbit l-Gulonate 3-Dehydrogenase/[lambda]-Crystallin: Insights into the Catalytic Mechanism
    Y Asada, C Kuroishi, Y Ukita, R Sumii, S Endo - Journal of molecular , 2010 - Elsevier
     
    4. Crystallization and preliminary X-ray crystallographic analysis of rabbit l-gulonate 3-dehydrogenase
    Y Asada, C Kuroishi, Y Ukita, R Sumii - Section F: Structural , 2008 - scripts.iucr.org
     

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    Protein Summary

    The gene AF2017 from Archaeoglobus fulgidus encodes the NP_070841.1 protein, a 3-hydroxyacyl-CoA dehydrogenase (3-HCDH) EC:1.1.1.35 COG1250 (alternative names: beta-hydroxyacyl dehydrogenase, beta-keto-reductase). Its sequence shows two domains, the N-terminal belonging to the HCDH NAD binding domain (PF02737), and the C-terminal  from the HCDH C-terminal domain group (PF00725).

    The 1zej structure N-terminal domain (1-160) belongs to the class of alpha and beta (a+b) proteins and reveals NAD(P)-binding Rossmann-fold domain fold type, inside the 6-phosphogluconate dehydrogenase-like N-terminal domain family (SCOP51734); the C-terminal domain (163-262) belongs to the 6-phosphogluconate dehydrogenase C-terminal domain-like superfamily, HCDH C-domain like family. According to DALI, 1zej shows structural similarity to

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    (Z=26),
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    (Z=26), and
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    (Z=26).

    3-Hydroxyacyl CoA dehydrogenases are classified as oxidoreductases.  They are involved in fatty acid metabolic processes.  Specifically they catalyze the third step of the beta oxidation of L-3-hydroxyacyl-CoA by NAD+. The reaction converts the hydroxyl group into a keto group: (S)-3-hydroxyacyl-CoA + NAD+ --> 3-oxoacyl-CoA + NADH + H+.

    Ligand Summary



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