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The Open Protein Structure Annotation Network
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1vkm

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold. Proteins 59 864-868 2005
    Site JCSG
    PDB Id 1vkm Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1290,TM1464, 84827
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 6
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.06 Rfactor 0.15384
    Waters
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    Solvent Content 40.36

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 1vkm
    1. The Buccaneer software for automated model building. 1. Tracing protein chains
    K Cowtan - Acta Crystallographica Section D: Biological , 2006 - scripts.iucr.org
     
    2. Crystal structure of an indigoidine synthase A (IndA)_like protein (TM1464) from Thermotoga maritima at 1.90 resolution reveals a new fold
    I Levin, MD Miller, R Schwarzenbacher - Proteins: Structure, , 2005 - Wiley Online Library
     
    3. A new approach to assess and predict the functional roles of proteins across all known structures
    ES Julfayev, RJ McLaughlin, YP Tao - Journal of structural and , 2011 - Springer
     

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    Protein Summary

    TM1464 encodes an indigoidine synthase A (IdgA)-like protein from Thermotoga maritima (pfam04227; COG2313). Indigoidine is a blue pigment first described in Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress [Ref]. IdgA is involved in indigoidine biosynthesis, but its specific function is unknown. Analysis of TM1464 genome context indicates a functional link (score 0.825) with TM1465, a cob(I)alamin adenosyltransferase.

    TM1464 structure, 1vkm, represents a novel fold (Indigoidine synthase A-like; SCOP sunid:110580), with a 3 layers (alpha/beta/alpha) core containing a parallel beta-sheet of 7 strands (order: 2134756). A DALI search returns no significant hits.

    Analysis of the crystallographic packing of 1vkm using the PQS server {Henrick, 1998 #73} indicates that an hexamer is the biologically relevant form.

    Ligand Summary



    References

    Reviews

    References

     

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