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1o3u

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution. PROTEINS 54 806-809 2004
    Site JCSG
    PDB Id 1o3u Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1221,TM0613, 89389
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 1.74 Rfactor 0.179
    Waters
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    Solvent Content 28.84

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 1o3u
    1. Microbial biochemistry, physiology, and biotechnology of hyperthermophilic Thermotoga species
    SB Conners, EF Mongodin, MR Johnson - FEMS microbiology , 2006 - Wiley Online Library
     
    2. Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for T. maritima proteins
    R Page, AM Deacon, SA Lesley - Journal of structural and , 2005 - Springer
     
    3. Autoindexing with outlier rejection and identification of superimposed lattices
    NK Sauter, BK Poon - Journal of Applied Crystallography, 2010 - scripts.iucr.org
     
    4. Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 resolution
    H Erlandsen, JM Canaves, MA Elsliger - Proteins: Structure, , 2004 - Wiley Online Library
     
    5. Exploring the Role of CH. Interactions on the Structural Stability of Single Chain All-Alpha Proteins
    V Shanthi, K Ramanathan - Applied biochemistry and , 2010 - Springer
     
    6. Comparing protein contact maps via Universal Similarity Metric: an improvement in the noise-tolerance
    S Rahmati, JI Glasgow - journal of computational biology and drug , 2009 - Inderscience
     
    7. End-to-end and end-to-middle interhelical interactions: new classes of interacting helix pairs in protein structures
    TS Ghosh, SK Chaitanya - Section D: Biological , 2009 - scripts.iucr.org
     
    8. Carbohydrate utilization pathway analysis in the hyperthermophile Thermotoga maritima
    SB Conners - 2006 - repository.lib.ncsu.edu
     
    9. The Universal Similarity Metric, applied to contact maps comparison in a two-dimensional space
    S Rahmati - 2008 - catspaw.its.queensu.ca
     
    10. Complete Prokaryotic Genomes: Reading and Comprehension
    MY Galperin, EV Koonin - Systems Biology: Genomics, 2007 - books.google.com
     

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    Protein Summary

    Gene TM0613 from Thermotoga maritima encodes the NP_228423 protein that contains a putative nucleotide-binding domain (HEPN) (COG2250; smart00748; Pfam05168) present in several bacterial drug resistance and human proteins involved in neurodegenerative processes (PubMed: 12765831, 14997578).

    It is unknown if TM0613 phylogenetic cooccurrence (detected using string.embl.de server) with TM0841 (S-layer-like array protein;  reviewed in PubMed: 10648507) and TM1652 is significant enough to implicate functional interdependence between those proteins.

    TM0613 structure, 1o3u, has a up-and-down four-helical bundle fold (SCOP sunid: 47161) and belongs to the SCOP family of HEPN domains (probable bi-partite nucleotidyltransferase subunit; SCOP sunid 89022). TM0613 predicted partner is a putative catalytic subunit encoded by TM0614. DALI top hits are with the TT1696 protein

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    (Z=18), the AF0298 protein
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    (Z=15) and the CO2003 protein
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    (Z=11).

    Ligand Summary



    References

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