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1o20

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution. Proteins 54 157-161 2004
    Site JCSG
    PDB Id 1o20 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1197,TM0293, 89367
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.57 Rfactor 0.16
    Waters
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    Solvent Content 51.67

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 1o20
    1. Structural biology of proline catabolism
    JJ Tanner - Amino acids, 2008 - Springer
     
    2. A Novel Two-domain Architecture Within the Amino Acid Kinase Enzyme Family Revealed by the Crystal Structure of Escherichia coli Glutamate 5-kinase
    C Marco-Marn, F Gil-Ortiz, I Prez-Arellano - Journal of molecular , 2007 - Elsevier
     
    3. Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor
    DW Wolan, CG Cheong, SE Greasley, IA Wilson - Biochemistry, 2004 - ACS Publications
     
    4. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor _-DADF identifies the folate binding site
    DW Wolan, SE Greasley, J Mark, SJ Benkovic - Biochemistry, 2003 - ACS Publications
     
    5. Pyrroline_5_carboxylate synthase and proline biosynthesis: From osmotolerance to rare metabolic disease
    I Prez_Arellano, F Carmona_lvarez - Protein , 2010 - Wiley Online Library
     
    6. Crystal structure of __glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 resolution
    R Page, MS Nelson, F von Delft - Proteins: Structure, , 2004 - Wiley Online Library
     
    7. Crystal structures of human bifunctional enzyme ATIC in complex with potent sulfonyl-containing antifolates
    CG Cheong, DW Wolan, SE Greasley - Journal of Biological , 2004 - ASBMB
     
    8. Of sequence and structure: Strategies of protein thermostability in evolutionary perspective
    IN Berezovsky, EI Shakhnovich - Arxiv preprint q-bio/0408007, 2004 - arxiv.org
     
    9. Protein Sequence Alignment Analysis by Local Covariation: Coevolution Statistics Detect Benchmark Alignment Errors
    RJ Dickson, GB Gloor - PloS one, 2012 - dx.plos.org
     
    10. Nucleotide and Amino Acid Sequences for Calmodulin Protein Methyltransferase
    RL Houtz, R Magnani, LMA Dirk - US Patent App. 12/757,388, 2010 - Google Patents
     

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    Protein Summary

    The TM0293 gene of Thermotoga maritima encodes gamma-glutamyl phosphate reductase (GPR; EC 1.2.1.41), an enzyme that catalyzes the second step of proline biosynthesis, the reversible nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of L-glutamyl phosphate to phosphate and L-glutamate 5-semialdehyde (PubMed:14705032).

    Protein encoded by TM0293 gene has ALDH-like fold (SCOP sunid:53719) with two similar domains (each with 3 layers a/b/a sandwich) with parallel beta-sheet of 5 strands (order 32145).

    Ligand Summary



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